The fact that chemotherapy loses effectiveness in advanced cancer stages is not unfamiliar. But, recent study shows that grape seed extract actually fights the cancer better if the disease is in more advanced stage.
Furthermore, it’s been discovered that the extract targets highly resistant cancer cells without harming the healthy ones. It’s been also confirmed that it works better than chemo when it comes to advanced stages.
The study that came to the discovery was conducted on colorectal cancer lines that represent every stage of the disease, at the University of Colorado Cancer Center and it has been published in the journal “Cancer Letters.”. While it takes more medications to kill cancer cells in the IV stage than in the II, with the extract it is the opposite.
“It takes less than half of the concentration to control the cell growth and destroy 50% of the cells in the IV stage, compared to the amount that is required to achieve similar results in the second stage. Colon cancer cells may have more than 11,000 genetic mutations — differences related to the DNA of the healthy cells. Traditional chemotherapy can target a specific mutation, and as the cancer grows the number of mutations increases. These changes may lead to resistance of the cancer to chemotherapy. On the other hand, many of the bioactive compounds in the grape seed extract can target more mutations. The efficacy of the extract grows as the number of mutations increases” –explains Molly Derry, a doctoral candidate in the laboratory of the University of Colorado.
According to scientists, grape seed extract causes oxidative stress that leads to programmed cell death, also known as apoptosis.
“For some time we knew that the bioactive compounds found in grape seeds selectively target many types of cancer cells. This study explains how most of the mutations that stimulate the colon cancer cells to metastasize and survive during traditional therapies, make these cells particularly sensitive to the grape seed extract treatment” explains Molly Derry.
During the study it’s been discovered that resveratrol, the active ingredient found in grape seeds and skin, offers numerous health benefits that besides helping the regeneration of nerves, cartilage, joints and spine, can also:
- Inhibit pancreatic cancer cell proliferation
- Protect against several types of viruses, although the whole process is still not scientifically determined. It is effective in treating herpes simplex type 1, Varicell-Zoster virus, human cytomegalovirus, Epstein-Barr virus, enterovirus type 71 (it can cause paralysis, including the heart as well)
- Inhibit colon cancer growth
- Cure stubborn fungal infections
- Protect against Alzheimer’s disease
- Protect the cardiovascular system
According to a research publushed in the journal of the American Association for Cancer Research conducted by researchers from the University of Kentucky, the extract kills 76% of the leukemia cells in 24 hours that were exposed to it. It also stimulates a protein known as JNK that regulates the destruction of cancer cells.
Because grape seeds lose their ability to interact with other substances during the processing and extraction, it is advisable, if possible, to use the whole plant or a certain part of the plant.